Crimson Publishers-Investigations in Gynecology Research & Womens Health

Abstract Disseminated Intravascular Coagulation (DIC), the most catastrophic obstetric acute emergency, is characterized by an inappropriate activation of coagulation & fibrinolytic system triggered by conditions like abruptio placentae & amniotic fluid embolism (release of thromboplastin intravascularly) or by diffuse endothelial damage as a result of pre-eclampsia. Clinical manifestation of severe bleeding and damaged coagulation profile are hallmarks of diagnosis, although histopathological demonstration of fibrin deposits is the pathognomonic feature of DIC. Understanding the basic pathophysiology, tackling the underlying etiological factor and replacement of the lost blood and specific components cover the principles of management of this condition. Keywords: DIC; FFP; Thromboplastin coagulation failure; Coagulopathy Abbreviations : DIC: Disseminated Intravascular Coagulation; HELLP: Hemolysis Elevated Liver Enzymes and Low Platelets Syndrome; IUFD: Intrauterine Fetal Dea...

Cervical cancer is the fourth leading cause of cancer and cancer death among women worldwide [1]. According to the International Agency for Research on Cancer (IARC) in 2018, the global incidence is estimated at 570,000 new cases per year, of which more than 80% occur in developing countries [1]. In Morocco, the cervical cancer represents a major public health problem. It ranks second, after breast cancer in Moroccan women [2]. The incidence of cervical cancer remains high among women living with HIV. However, many studies have shown that this population has an increased risk of developing intraepithelial cervical neoplasia [3]. In the fight against cervical cancer, Morocco has a national cancer control programme under the aegis of the LALLA SALMA Foundation since 2006, thus enabling the creation of reference centers for screening and diagnosis of cervical cancer [4]. Women living with HIV often escape this program because of fear of stigmatization and disclosure of their HIV status. I...

Peripheral and central sensitizations are conditions of the nervous system that are characterized by increased tone and responsiveness, a lower threshold for the experience of pain and a tendency for pain to persist long after the original stimulus has ended [1]. The mechanism of the development of chronicity is under intense investigation involving a variety of important biochemical and sensitization processes. From a clinical perspective however, the situation can be summed up that pain per se, if not kept under control, may initiate the processes causing the transition from acute to chronic pain. Basic Investigations Investigations into the origins of central sensitization in particular, have focused on the role of continuous peripheral drive from the nociceptors (defined as neurons that are activated by noxious stimulation). It has been shown these nociceptors can become sensitized after being injured and develop a lower threshold for activation. Further, the persistence of affer...

Introduction: South Africa has one of the highest rates of sexual violence against females in the world [1,2]. Residual outcomes among rape survivors in South Africa are complex, and include symptoms of depression, and post-traumatic stress (PTSS) [3,4] as well as physical and gynecological problems [5,6]. While South African rape survivors report physical and mental health symptoms [7]. We know little about the internal (i.e. self-management) and external (i.e. support from others) coping strategies that they use over time.   Objectives: This study conducted secondary analyses of South African female rape survivors who reported experiences of rape within six months of being interviewed and compared their physical and mental health, coping strategies, rape myths and social undermining of friends and families one year later. The goal is to foster a discussion of post-rape outcomes that may be utilized to develop recovery interventions for South African women rape survivors who may...

The SARS-CoV 2 pandemic is now responsible for over 48 million infections and one million deaths worldwide. Pandemics impact population growth not only by excessive mortality, but also by preventing births. In previous pandemics occurring in the 20 th and 21 st centuries, a trend towards birth rate reduction was observed 9 months later (Figure 1). After the 1918-20 HIN1 influenza pandemic, birth rates dropped by 5 to 15% in comparison to average rates before the pandemic [1]. This drop was related to higher death rates in pregnant patients (case fatality rate of 27%), as well as miscarriages and stillbirths (increased by 0.4% and 2.2% respectively as compared to prior average rates) [1,2]. A rebound in birth rates, however, occurred 1-2 years after this decline [3]. Moreover, several studies have shown that children born in 1919, and thus exposed to the H1N1 virus in utero, experienced worse health and socioeconomic outcomes in older ages than surrounding birth cohorts [4]. SARS-CoV ...

  There are perspectives to cure breast cancer, and the main strategy in that way is the exact estimation of tumor dissemination at diagnosis. It is well proved that disseminated tumor cells in the bone marrow are the most important prognostic factor in operable breast cancer [1]. Its prognostic role become visible at late periods after surgery (sometimes, 25 years). Taking in mind that women with breast cancer are around 60-year-old, one may see that the relapses arises usually after 80. It appears in brain, lung and other distant organs as hematologic metastases, and unfortunately, nothing is possible to do in the most of those cases, so the main reasons of deaths in breast cancer are distant metastases. Hematological dissemination of breast cancer takes place at very early stages of the diseases, sometimes even at carcinoma in situ [2]. The main reservoir of tumor cells in the organism is bone marrow [3,4]. Those cells survive for a long time and then wake up and come to some ...

Postmenopausal osteoporosis is a silent disease with not much of symptoms until fractures occur. It is characterized by low bone mineral density (BMD) and changes in bone microarchitecture that reduces bone strength and there is increase in risk of fractures [1]. After menopause, estrogen deficiency is the major contributing factor. Because of this there is an increase in RANK-ligand (RANKL) and a decrease in osteoprotegerin (OPG) secretion from osteoblasts. This imbalance induces fast bone loss, and thus there is increase in risk of fractures. WHO has identified osteoporosis as a major public health concern [2]. Osteoporosis is widely recognized as an important public health problem because of the significant morbidity, mortality and costs associated with its complications-namely fractures of the hip, spine, forearm and other skeletal sites [3]. The incidence of fragility fractures is highest among elderly white women, with one in every two women suffering an osteoporosis related frac...

Fibroadenoma and phyllodes tumor are fibroepithelial lesions, thus may have similar histopathological appearance and share overlapping clinical as well as radiological features. The distinction between these two lesions is clinically important as both lesions have different management. There is substantial overlap between fibroadenomas and phyllodes tumors. We present a similar case report of a 23 years-old female patient with classical radiological features of phyllodes tumor, which turned out to be a giant type of fibroadenoma on histopathology after surgical excision. Keywords: Giant fibroadenoma; Phyllodes; Mammography; Ultrasound; MRI Abbreviations: BIRADS: Breast Imaging-Reporting and Data System Introduction Fibroadenoma is a benign lesion, accounting for well over half of breast tumors, while phyllodes tumor have spectrum of diseases ranging from benign to malignant lesions, accounting for 1% of all breast neoplasms [1]. Fibroadenoma and phyllodes tumor are fibroepith...

Body Image and Female Sexual Functioning: Impacton Health Service Delivery in a Developing Country Context by VM Lema* in  Gynecology Open Access Journals Female sexuality is complex and highly contextual, influenced by among others one’s body image and self-esteem. Body image experiences are integral to the quality of an individual’s life including sexual function. Research findings have linked evaluations and cognitions interference with sexual responses and experiences during sexual activity. They may lead to sexual dysfunction, sexual aversion, avoidance and risky sexual behaviors. This paper presents three young Black African women with perceived poor body image of different parts of the body namely the breasts, weight and configuration and external genitalia, and impact thereof on their sexual functioning. They all were counselled and supported to accept who they were, two of whom made significant improvement. The potential impact of body image concerns on reproduc...

Two Useful Safe Products for Maintaining HealthyVagina and Prevention of Infection with HumanPapilloma Virus leading to Carcinoma of Cervix by Talwar GP*in Investigations in Gynecology Research & Womens Health We developed a Poly-herbal formulation named as BASANT, which has remarkable properties of inhibiting a wide spectrum of genital infections. It inhibits all WHO (World Health Organization) strains of N. gonorrhoeae including those strains resistant to Penicillin, Tetracycline. Nalidixic acid and Ciprofloxacin [1] it has pronounced inhibitory action against Candida glabarata, Candida albicans, and Candida tropicalis isolated from women with vulvovaginal candidacies, including strains resistant to azole drugs and amphotericin [1]. BASANT has inhibitory action on free as well as within cells contained Chlamydia trachomatis  https://crimsonpublishers.com/igrwh/fulltext/IGRWH.000533.php For more open access journals in  crimson publishers  please ...