Crimson Publishers-Investigations in Gynecology Research & Womens Health

Abstract Objective: Cancer of unknown primary in pregnancy is scarcely reported in literature. The mortality is very high and less than 25% survive beyond 1 year. The non-specific symptoms of pregnancy together with limited safe diagnostic modalities delays its early diagnosis hence resulting in the advanced stage of presentation with fatal outcome. Case report: We present a case of 30-year-old G3 A2 at 27 weeks amenorrhea with non-specific complaints of weakness of both lower limbs which on MRI revealed pathological fracture of T12 vertebra and a mass in the iliac region. Biopsy from the iliac mass revealed undifferentiated adenocarcinoma which suggested metastasis. Patient underwent LSCS at 30 weeks followed by spinal fixation for the pathological fracture on post-operative day 9. After two days of spinal fixation patient succumbed to cardiac arrest. Conclusion: Due to its rarity with acute deadly outcome, the previous literature related to the patients of cancer of unknown pr...

Abstract Background: A healthy receptive endometrium is essential for embryo implantation. Recently, the relationship between chronic endometritis (CE) and infertility-related conditions such as previous implantation failure has emerged as an area of inquiry. Objective: To evaluate the prevalence of CE in women with previous IVF/ICSI failure using hysteroscopy and CD138 immunohistochemistry and to determine whether subsequent antibiotic treatment positively impacts outcome in these cases. Design: prospective cohort study. Setting: El-Shat by Maternity University Hospital. Materials and methods: 145 women with history of previous IVF/ICSI failure underwent hysteroscopy and endometrial sampling for CD138 immunohistochemistry detection. Patients were placed in two groups based on presence or absence of CE (group 1 and 2 respectively). Patients in group 1 underwent treatment with oral antibiotics for at least 3 weeks until repeat follicular phase biopsy showed no CE. Primary...

  Abstract Background: In infertile men with severe oligospermia (sperm concentration <5million/mL) undergoing ICSI the choice between using ejaculated sperm or testicular sperm remains controversial. Testicular sperm have shown lower levels of DNA damage compared with ejaculated spermatozoa from the same individuals. Objective: To compare intracytoplasmic sperm injection (ICSI) outcome in patients with severe oligospermia using testicular versus ejaculated spermatozoa. Design: Retrospective cohort study.   Setting: Medina Fertility Center Materials and Methods: Patients with severe oligospermia who underwent ICSI cycles with either testicular or ejaculated sperm between January 2015 and December 2017 were included in this study. 205 couples met the study criteria after exclusion of cycles with mixed sperm sources. Patients were divided into 2 subgroups according to the source of sperm used in intracytoplasmic sperm injection (ICSI) cycle; (Group A) included 1...

  Abstract Vaginal contraceptive products have been available for many years and usually contain the membrane surfactant nonoxynol-9 (N-9) as one of the main ingredients. However, the major drawback of using surfactants is their detergent-type cytotoxic effect on vaginal cells. Besides, N-9 is also known to inactivate lactobacilli leading to disturbance of the vaginal microflora, which in turn increase the chances of STI/HIV transmission. Neem seed oil proved to be spermicidal against rhesus monkey and human spermatozoa in vitro. Hexane extract of neem seed was reported to be precursor for immune contraceptive guided fraction whereas lyophilized neem leaf extract which is hydrophilic in nature has shown spermicidal activity against human spermatozoa in vitro. This review article proposes hydrophilic lipid for the extraction of hydrophilic and hydrophobic constituents from neem leaf to give novel aqueous neem leaf extract (NANE) which involves no use of organic solvent or therma...