Vitamin D and Ovarian Cancer_Crimson publishers


Vitamin D and Ovarian Cancer by Shipra Sonkusare in Gynecology Research & Womens Health


Ovarian cancer causes more deaths than any other cancer of the female reproductive system. The vitamin D receptor (VDR) is weakly to moderately expressed in normal ovarian cell, but is more strongly expressed in ovarian cancer line and tumor tissue. In vitro studies have reported that vitamin D administration inhibits cell growth and induces apoptosis in a dose dependent manner in both animal and human ovarian cancer cell lines.With available literature in the background, there is an urgent need to conduct a large case control trial to evaluate the association of vitamin D receptor gene polymorphism Fok1 with the risk of epithelial ovarian cancer. Also, we need to evaluate the levels of serum vitamin D in epithelial ovarian cancer patients.

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