Clinical Features of Pathological Processes of the Cervix Associated with Human Papillomavirus Infection

Abstract

Background: Cervical Diseases associated with Papillomavirus infection are one of the most pressing

problems modern gynecology due to the high frequency of occurrence (in the structure gynecological

morbidity - from 20 to 45%) and the ability to steady progression of the pathological process. A

significant place in the structure of CM pathology is occupied by cervical intraepithelial neoplasia (CIN),

which are often malignancy. Of particular importance are the issues of oncological transformation of the

cervix in patients of reproductive age, taking into account the upcoming implementation of reproductive

function. In Russia over the past 15 years, there has been an increase in the proportion of neglected

cases of cervical cancer (cervical cancer), which ranks second (after breast cancer) in the structure of

malignant tumors in reproductive age in women. Unfortunately, to date, the data of only an anamnesis,

general clinical laboratory and instrumental methods of research are not productive enough to assess the

risk of developing cervical onychopathology.

Objective: To identify the most significant clinical and anamnestic risk factors for the progression

of pathological processes associated with human papillomavirus infection and the development of

malignant transformation of the cervix in women of reproductive age, as they are important, taking into

account statistical analysis.

Material and methods: The study conducted prospective and retrospective analyzes of 185 patients

of reproductive age with cervical diseases; the age of the women surveyed ranged from 25-44 years.

Results: We have revealed a moderate relationship (using Spearman’s correlation analysis) between

the degree of progression of cervical disease and the presence of aggravated heredity (cancer of the

reproductive system) (R = 0.5679, p1.0, which allowed us to attribute these factors of hereditary burden

to cancer with statistically significant risk factors for malignant transformation and progression of the

pathological process of cervix.

Conclusion: According to our study the most clinically and statistically significant risk factors are high

virus HPV an oncogenic risk of more than 105 genomic equivalents; HPV persistence of high oncogenic

risk; previously morphologically verified CIN; sexually transmitted mixed infections (3 or more).

Keywords: HPV; CIN; Cervical cancer; Gynecological oncology

Read More About Crimson Publishers: https://crimsonpublishers.com/

Crimson Publishers-Investigations in Gynecology Research & Womens Health